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![]() I notice their response to the story and use it to guide my storytelling with them in the future. ![]() Sometimes patients find stories distracting, so I often ask permission before I begin. I wait until I know a patient well enough to determine which stories will be most useful, and I select specific illustrations tailored to individual needs. And if I tell you how I solved a problem, you won’t need to reinvent the wheel. (Other peoples’ stories are adapted to provide anonymity.) Two common themes are “your experience is common you are normal” and “here’s how someone addressed a problem similar to the one you are facing.” If I tell you of my mistakes, perhaps you won’t have to make them yourself. Over the years I have collected stories, from my life and the lives of others, which I use as fables, each with a specific message intended. Storytelling involves 3 skill sets: knowing the stories, choosing when to tell them, and telling them effectively. This cements the information in my own mind alerts me to any gaps in the story allows the patient to correct any mistakes and enhances the doctor-patient relationship by confirming that I was truly listening. Once the story is complete, I give an abbreviated version back to the patient. Whenever a patient says, “I’ve never told that to anyone before,” the story is always of great importance. Often what is missing turns out to be of greater importance than what is said. This enhances my own memory of the experience and allows me to recall details afterward with great precision. If there’s a moment missing, a detail gone astray, I track it down to fill in the gap. Taking a history is like painting a picture or watching a movie. When emotional issues are at the forefront, a non-directive approach is most likely to allow the patient to speak from the heart. While directive interviewing can be useful with a checklist questionnaire, such as an anesthetist might use, interactive interviewing is far more efficient for most purposes-allowing the patient to take the lead, with some input from a physician to stay on track and to fill in important details. But too much control can be as inefficient as none at all. ![]() I managed to summarize the story for my preceptor in 10 minutes he encapsulated its essence in 15 words: “You have a 65-year-old depressed hypertensive woman who is noncompliant with her medication.”Ī common mistake is to take over the narrative, to provide the structure that the patient lacks. I vividly remember interviewing one of my first patients in my family medicine residency program. To compensate, a good listener needs to acquire these skills. They don’t know how to focus a narrative, structure it linearly, abstract the important, and omit the trivial. Many patients are not intrinsically good storytellers. It's clear the designers put in a lot of effort to give the chuzzles - little more than balls of fur with eyes - a lot of personality. Aside from fashion, the chuzzles also squeak, sneeze, glare, or giggle depending on the player's actions or inaction if you walk away from the game without pausing it, the chuzzles will actually fall asleep. Random chuzzles also flaunt their fashion sense by wearing outrageous sunglasses - too bad the glasses don't earn the player any extra points. Explode a super chuzzle and watch the whole board shake. The fur on each chuzzle ripples, eyes blink and follow the mouse pointer, and when the chuzzles explode, fur flies across the screen. Finally, there is Mind Bender, which is a lot like those little tray puzzles where you move one line at a time until the picture is correct.Īs with most PopCap games, the graphics in Chuzzle are high resolution and rich in detail despite the simple subject matter. Speed Chuzzle pits the player against a timer that is sure to raise blood pressure Zen Chuzzle does the opposite, lulling the player into a calm state of being with a never ending shuffle of the furry creatures. ![]() Four main modes of play are available: "Classic," "Speed," "Zen," and "Mindbender."īuilding on the free online version of Chuzzle (a.k.a "Classic Chuzzle"), Chuzzle Deluxe offers two levels of play for Classic Chuzzle and adds three other variations on the game. The object of the game is to remove Chuzzles from the board, by arranging them so that three or more of the same color are grouped together. The Chuzzle playfield is full of cute, colorful, blobs of fur, called "Chuzzles," that come alive through their voices, animations, and googley eyes. If you enjoy simpler games like the first Bejeweled, then you'll probably like this one too.This action-puzzle game of online origin was developed by PopCap, the creators of the popular Bejeweled. While that's basically all this game entails, it's still a fun little timewaster. All it takes to remove a lock is to include the trapped Chuzzle in a match, which is often easier said than done. Locks can quickly make it impossible to make a useful move, so you need to get rid of them fast. As long as it's locked down, you won't be able to move the column and row it's in. These randomly appear and grab a Chuzzle, anchoring it to that location. They also can't fit under the sides of the playfield, limiting how far you can move them. But large Chuzzles, who are twice the size of their brethren, require you to shift both columns or rows that they occupy. ![]() Normally, you move an entire column or row, with the Chuzzles on the ends wrapping around to the other side of the playfield. The two other obstacles interfere with your ability to move the Chuzzles around. You have a limited number of shuffles, and thus there's a limit on how long you can play. When this happens, you need to shuffle the game in order to continue. The main obstacle here is the size of the gameplay area: it's only 6圆, which makes it easy to run out of possible moves. While being able to move entire columns and rows makes it easier to find a match than the usual mechanics found in these games, no game would be fun if there wasn't an obstacle or two to get in your way. Once the beaker is full, it releases all of the collected Chuzzle energy is a shower of sparkles and the next level begins. When they form a group, they pop into pure magic that floats through the air and returns to the beaker on the left side of the screen. You also don't need to worry about aligning them to columns or rows, as any group of three or more Chuzzles with the same fur color will match, regardless of the shape their formation takes. Instead of matching tiles or gemstones, you're working with these cute fuzzballs called "Chuzzles". ![]() ![]() Chuzzle Deluxe is an adorable little Match 3, though there are a few differences from the standard design. ![]() ![]() Additionally, several explanatory models have been proposed that have usefulness, both in theoretically understanding suicidal behavior among cohorts, and in providing an organized manner by which to characterize specific and dynamic risk factors in individual patients. Interventions geared toward increasing social support, safety (by reducing access to lethal means e.g., firearm), protective obstacles, hotlines, and education of the public have been recommended as universal ( 5– 7) and selective ( 3, 6, 8) interventions. Suicidal behavior (including fatal and non-fatal suicidal self-directed violence) is a multi-factorially determined phenomenon ( 3, 4) in which predispositions and triggers, protective and aggravating factors, availability of means, social and professional supports, as well as deterrents, all interact in a reciprocal interplay that determines short- and long-term risk and prognosis. Moreover, every death by suicide is accompanied by 10–20 suicide attempts, leading to an annual number of global suicide attempters of ~10 million ( 2). Thus, randomized interventional studies are necessary to advance causal inferences and, if causality is confirmed, to provide hope that an etiological treatment for a distinct subgroup of individuals at an increased risk for suicide could emerge.Īnnually, 0.8 million individuals worldwide die by suicide ( 1). Yet, causality has not been demonstrated. gondii seropositivity in both the psychiatrically healthy as well as in patients with Intermittent Explosive Disorder. Trait impulsivity and aggression, endophenotypes of suicidal behavior have also been positively associated with T. gondii IgG (but not IgM) seropositivity and serointensity. In sum, an abundance of evidence supports a positive link between suicide attempts (but not suicidal ideation) and T. gondii and biomarkers previously associated with suicidal behavior (kynurenines, phenylalanine/tyrosine), intermediate phenotypes of suicidal behavior (impulsivity, aggression) and state-dependent suicide risk factors (hopelessness/dysphoria, sleep impairment). Finally, the article introduces certain links between T. Then, it reviews findings from all three meta-analyses published to date, confirming our reported associations and overall consistent in effect size. This “legacy” article presents, chronologically, our primary studies in individuals with mood disorders and schizophrenia in Germany, recent attempters in Sweden, and in a large cohort of mothers in Denmark. gondii IgG serology and suicidal behavior in persons with mood disorders. gondii serology and suicidal behavior, a field of study that started 15 years ago with our publication of associations between T. This paper is a detailed review of the associations between T. gondii's associations with suicidal behavior, as well as trait impulsivity and aggression, mental illness and traffic accidents. This is related to the parasite's neurotropism, high prevalence of chronic infection, as well as specific and non-specific behavioral alterations in rodents that lead to increased risk taking, which are recapitulated in humans by T. Within the general literature on infections and suicidal behavior, studies on Toxoplasma gondii ( T. ![]() Moreover, its intuitive design keeps everything straightforward. The anti-malware and password manager are excellent, the VPN is basic but effective, and the bonus features are plentiful. Key takeaway: Panda’s antivirus software for Windows is outstanding. Parental controls cost extra: Panda’s full parental controls are not included, even with the expensive Panda Dome Premium.It’s not worth the $ 50 upgrade from Panda Dome Complete to Premium. Basic VPN: It does not have a kill switch or split tunneling.Password manager only supports Chrome and Firefox: It would be great if other browsers, like Edge and Safari, were also supported.We prefer Norton on macOS, which also includes an unlimited VPN. Limited Features on macOS: Panda lacks a firewall, and its design is a bit bated.But novices, don’t worry, the default settings work excellent as well. 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I remember things like 1) the true implications of the volitional form (I would say I genuinely had to relearn this at some point in intermediate study), 2) topic-subject constructions and 3) the idea of when to use passive voice in Japanese vs. I learned from Genki I and II in high school and early college, then finished an intermediate course at my university (the last offered, which completed my minor), then didn’t use it in any serious way for six years and resumed serious self-study after coming to Japan. ![]() I took and passed JLPT N3 after Integrated Approach to Intermediate Japanese, and then got distracted with other things after 中級から上級への日本語, so I never got around to taking N2, I could probably pass it with a bit of a refresher though. I also supplemented things with the Dictionary of Basic Japanese Grammar and Dictionary of Intermediate Japanese Grammar. I used Genki I, II, Integrated Approach to Intermediate Japanese, and 中級から上級への日本語, and I didn’t feel like I had to unlearn anything along the way. I found it explained the grammar points simply and effectively. That’s interesting, I didn’t have that experience using Genki at all. ![]() (a) Differentially co-expressed module networks with the DiffCorr package. Specifically, it has 15842 nodes and 49812 edges. Figure 1.7 Module network visualization with the DiffCorr package and Cytoscape. Several case studies of Cytoscape plug-ins are surveyed, including a search for interaction pathways correlating with changes in gene expression, a study of protein complexes involved in cellular recovery to DNA damage, inference of a combined physical/functional interaction network for Halobacterium, and an interface to detailed stochastic/kinetic gene regulatory models. Which is the best way for visualizing a big network in Cytoscape I'm using Cytoscape for visualizing my transcriptional network, but it is huge. The Core is extensible through a straightforward plug-in architecture, allowing rapid development of additional computational analyses and features. Interactive network visualization in Python and Dash, powered by Cytoscape.js - GitHub - plotly/dash-cytoscape: Interactive network visualization in Python. Cytoscape is not too hard to use, but it won’t make much sense unless you have a sense of some basic network analysis vocabulary and concepts. Cytoscape's software Core provides basic functionality to layout and query the network to visually integrate the network with expression profiles, phenotypes, and other molecular states and to link the network to databases of functional annotations. Cytoscapeis a tool for viewing and analyzing networks(meaning, in this case, any group of entities that are connected in some way). Information to browse the database and use its. The ggpubr package was used to perform Spearman correlation analysis on these hub genes. Designed to find pathways and network patterns related to cancer and other types of diseases. Although applicable to any system of molecular components and interactions, Cytoscape is most powerful when used in conjunction with large databases of protein-protein, protein-DNA, and genetic interactions that are increasingly available for humans and model organisms. Then, Cytoscape plugin-Analyze Network was used to screen the significant modules with the degree >3 in the PPI network, and hub genes from CS-DEGs were obtained. ![]() Cytoscape is an open source software project for integrating biomolecular interaction networks with high-throughput expression data and other molecular states into a unified conceptual framework. ![]() ![]() When the Text Bar is visible, thats a dead giveaway, but you are also on the text layer if the Sound Bar is visible or if none of the document tool bars is showing. Since graphical elements can appear on either the text or graphics layer, you need to understand what each is used for.Īs a rule of thumb, if your Graphics Bar isnt showing, youre on the text layer. The text layer and the graphics layer interact in important ways, as we will see shortly. The front and back layers are collectively referred to as the graphics layer. On the front and back layers you have a different set of tools at your disposalthe graphics tools, which enable you to create, edit, and format graphics. The tools available on the text layer enable you to enter, edit, and format text. Most of your work will be done on the text layer, which is the middle transparency by this analogy. ![]() This is a good analogy for the way Nisus Writer handles text and graphics. You can see all three, but there are some things that are in front of your main text layer and some other things behind it. You have, in essence, a document that is three layers deep. Now imagine placing another transparency in front of it, and a third behind it. Picture your document printed on a transparency. Lastly, well explore special graphical elements like movies, page graphics, tables, and equations. Then well look at how graphical objects are created (or imported) and manipulated in your document and how text and graphics interact. Well begin by discussing the different layers Nisus Writer uses to store text and graphics. Still, Ive tried to include all the important details and anticipate the most commonly-asked questions. (In Chapter 6 well look at the sound features.)ġ20 This chapter is intended to give just an overview of the graphics tools, not to be comprehensive. In this chapter, well look at the tools and features available for adding all kinds of graphical elements to your documents. If you take a look at the box Nisus Writer comes in (or choose About Nisus® Writer from the Apple menu), youll notice that its called The Powerful Document Processor. This slogan was chosen because the term word processor is inadequate to describe an application that can produce documents rich with graphics, sounds, and video as well as text. Why and how to use tables and equations.How to add QuickTime movies to your documents.Techniques for combining text and graphics.How to import graphics from other applications.How to create drawings using Nisus Writers graphics tools.The differences between the text and graphics layers.So that's at least a solution for real tables and not only a limited construction with the make table command.119 Chapter 5. Now you can work as described above.Īnother solution is, to copy the cells(!) of another table or spreadsheet and copy these cells in the text field in your shape. The fields in table inspector are only activated, when there is at least one sign in it. Then type any character and ctrl/right-click. ![]() The other workaround was my first solution and I write down this solution here for those not having Nisus Writer Pro available and you might use any table or spreadsheet therefore.Ĭhoose any shape from a stencil in OmniGraffle (it works with connection lines too), where you can place text in it. It might work, because Nisus Wirter Pro and OmniGraffle Pro support Link Back. I hadn't tried out, whether Link Back is working too. And you will see, that those tables already have header and footer rows. Especially when you enable "resize to fit" you will get a really self-adjusting table. Of course you can change the text attributes with the text inspector as well. Now in the table inspector you have the possibility to add rows and columns, to change alignment, cell borders and cell background. To view the table inspector select a cell in the pasted table and ctrl/right-click. 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